Overview of the Use of Antihypertensive Agents by Adults Covered by the Québec Public Prescription Drug Insurance Plan

03-27-2012 | 

The studies reviewed on the use of antihypertensive drugs raised several issues. These related especially to poor adherence to recommended initial treatments and to the significant decline in persistence with antihypertensive therapy over time of use. Furthermore, no recent data are available on the quality of the use of antihypertensive drugs in Québec even though the population is aging and blood pressure gradually increases with age.

The objectives of this study were to provide an overview of the use of antihypertensive drugs from 2007 to 2009 among the beneficiaries of the public prescription drug insurance plan (Régime public d’assurance médicaments, RPAM) aged 18 years or older, and also to compare the use of antihypertensive drugs against optimal use criteria in order to measure compliance with them. A descriptive, historical cohort study was conducted to achieve these objectives.

The classes of antihypertensive agents most commonly used in monotherapy during the three study years were ACEIs and especially ARBs. The same two classes were also the most commonly used in combination, especially with diuretics, administered more easily as various fixed-dose formulations. Even if the compliance rates with CHEP criteria were generally high, it would be interesting to conduct a further study to assess a greater interdisciplinary approach would help improve treatment persistence and compliance with CHEP recommendations among new users.

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